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    Why axolotls seem to be everywhere — except in the one lake they call home
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    Scientist Dr. Randal Voss gets the occasional reminder that he’s working with a kind of superstar. When he does outreach events with his laboratory, he encounters people who are keen to meet his research subjects: aquatic salamanders called axolotls.

    The amphibians’ fans tell Voss that they know the animals from the internet, or from caricatures or stuffed animals, exclaiming, “‘They’re so adorable, we love them,’” said Voss, a professor of neuroscience at the University of Kentucky College of Medicine. “People are drawn to them.”

    Take one look at an axolotl, and it’s easy to see why it’s so popular. With their wide eyes, upturned mouths and pastel pink coloring, axolotls look cheerful and vaguely Muppet-like.

    They’ve skyrocketed in pop culture fame, in part thanks to the addition of axolotls to the video game Minecraft in 2021. These unusual salamanders are now found everywhere from Girl Scout patches to hot water bottles. But there’s more to axolotls than meets the eye: Their story is one of scientific discovery, exploitation of the natural world, and the work to rebuild humans’ connection with nature.

    A scientific mystery
    Axolotl is a word from Nahuatl, the Indigenous Mexican language spoken by the Aztecs and an estimated 1.5 million people today. The animals are named for the Aztec god Xolotl, who was said to transform into a salamander. The original Nahuatl pronunciation is “AH-show-LOAT”; in English, “ACK-suh-LAHT-uhl” is commonly used.
    Axolotls are members of a class of animals called amphibians, which also includes frogs. Amphibians lay their jelly-like eggs in water, and the eggs hatch into water-dwelling larval states. (In frogs, these larvae are called tadpoles.)

    Most amphibians, once they reach adulthood, are able to move to land. Since they breathe, in part, by absorbing oxygen through their moist skin, they tend to stay near water.

    Axolotls, however, never complete the metamorphosis to a land-dwelling adult form and spend their whole lives in the water.

    “They maintain their juvenile look throughout the course of their life,” Voss said. “They’re teenagers, at least in appearance, until they die.”

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    Water and life
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    Lightning is a dramatic display of electrical power, but it is also sporadic and unpredictable. Even on a volatile Earth billions of years ago, lightning may have been too infrequent to produce amino acids in quantities sufficient for life — a fact that has cast doubt on such theories in the past, Zare said.

    Water spray, however, would have been more common than lightning. A more likely scenario is that mist-generated microlightning constantly zapped amino acids into existence from pools and puddles, where the molecules could accumulate and form more complex molecules, eventually leading to the evolution of life.

    “Microdischarges between obviously charged water microdroplets make all the organic molecules observed previously in the Miller-Urey experiment,” Zare said. “We propose that this is a new mechanism for the prebiotic synthesis of molecules that constitute the building blocks of life.”

    However, even with the new findings about microlightning, questions remain about life’s origins, he added. While some scientists support the notion of electrically charged beginnings for life’s earliest building blocks, an alternative abiogenesis hypothesis proposes that Earth’s first amino acids were cooked up around hydrothermal vents on the seafloor, produced by a combination of seawater, hydrogen-rich fluids and extreme pressure.
    Yet another hypothesis suggests that organic molecules didn’t originate on Earth at all. Rather, they formed in space and were carried here by comets or fragments of asteroids, a process known as panspermia.

    “We still don’t know the answer to this question,” Zare said. “But I think we’re closer to understanding something more about what could have happened.”

    Though the details of life’s origins on Earth may never be fully explained, “this study provides another avenue for the formation of molecules crucial to the origin of life,” Williams said. “Water is a ubiquitous aspect of our world, giving rise to the moniker ‘Blue Marble’ to describe the Earth from space. Perhaps the falling of water, the most crucial element that sustains us, also played a greater role in the origin of life on Earth than we previously recognized.”

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    Water and life
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    Lightning is a dramatic display of electrical power, but it is also sporadic and unpredictable. Even on a volatile Earth billions of years ago, lightning may have been too infrequent to produce amino acids in quantities sufficient for life — a fact that has cast doubt on such theories in the past, Zare said.

    Water spray, however, would have been more common than lightning. A more likely scenario is that mist-generated microlightning constantly zapped amino acids into existence from pools and puddles, where the molecules could accumulate and form more complex molecules, eventually leading to the evolution of life.

    “Microdischarges between obviously charged water microdroplets make all the organic molecules observed previously in the Miller-Urey experiment,” Zare said. “We propose that this is a new mechanism for the prebiotic synthesis of molecules that constitute the building blocks of life.”

    However, even with the new findings about microlightning, questions remain about life’s origins, he added. While some scientists support the notion of electrically charged beginnings for life’s earliest building blocks, an alternative abiogenesis hypothesis proposes that Earth’s first amino acids were cooked up around hydrothermal vents on the seafloor, produced by a combination of seawater, hydrogen-rich fluids and extreme pressure.
    Yet another hypothesis suggests that organic molecules didn’t originate on Earth at all. Rather, they formed in space and were carried here by comets or fragments of asteroids, a process known as panspermia.

    “We still don’t know the answer to this question,” Zare said. “But I think we’re closer to understanding something more about what could have happened.”

    Though the details of life’s origins on Earth may never be fully explained, “this study provides another avenue for the formation of molecules crucial to the origin of life,” Williams said. “Water is a ubiquitous aspect of our world, giving rise to the moniker ‘Blue Marble’ to describe the Earth from space. Perhaps the falling of water, the most crucial element that sustains us, also played a greater role in the origin of life on Earth than we previously recognized.”

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